Metabolic

SLU-PP-332 · UK research stock

Synthetic pan-ERR agonist small molecule studied as an exercise mimetic in metabolic research

Size

£24.90

SKU SLUPP332-5 · Out of stock

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Same-day dispatch on orders before 2pm (Mon–Fri) · Royal Mail Tracked 24

Free shipping on orders over £80

Free research vial with every order over £120

Research use only. This product is sold strictly for in-vitro laboratory research by qualified professionals. It is not for human or veterinary use.

About SLU-PP-332

A synthetic small molecule, not a peptide, SLU-PP-332 belongs to a series of estrogen-related receptor (ERR) agonists developed from a pyrimidinetrione scaffold. It is an analogue built by medicinal chemistry rather than a fragment or copy of anything endogenous. The parent compound acts as a pan-ERR agonist with roughly four to fivefold selectivity for ERRalpha over ERRgamma ^[1]. ERRs are orphan nuclear receptors that govern transcriptional programmes for mitochondrial biogenesis and fuel selection.

Most of the interest comes from its description as an exercise mimetic. In mouse work, treatment induced DDIT4 through ERRalpha and switched on a transcriptional programme resembling the response to a bout of aerobic exercise ^[1]. Reported outcomes in those animals included more oxidative muscle fibres, higher fatty acid oxidation and greater running endurance ^[1]. Related pan-ERR agonists from the same programme have been studied in heart failure models, where the proposed mechanism is improved cardiac fatty acid metabolism and mitochondrial function ^[2]. ERR agonism has also been examined in the ageing kidney, again with mitochondrial function and inflammation as the readouts ^[3].

The evidence base is preclinical and small. It rests on cell assays and rodent models from a limited number of laboratories; there are no clinical trials, and the compound holds no medicines approval in the UK or elsewhere. Anti-doping chemists have characterised its in vitro metabolites for detection purposes, which indicates expected misuse in sport rather than any accepted use ^[4].

Because it is a small molecule, handling differs from the peptides it is often shelved beside. Rapid clearance in rodents prompted follow-up chemistry on the scaffold, yielding analogues such as SLU-PP-915 and other optimised ERR agonists ^[5].

Also sold as

SLU-PP-322

Research area

Metabolic

Purity

≥99%

Form

Lyophilized powder

Sizes

5 mg

Storage

Store at -20°C. Keep away from light.

Sizes, codes and availability
Size	SKU	Price	Availability
5 mg	SLUPP332-5	£24.90	Out of stock

Dispatch and delivery

Orders placed before 2pm Monday to Friday are dispatched the same day, by Royal Mail Tracked 24 in discreet packaging.

Shipping is £4.99, free on orders over £80.

A free research vial comes with every order over £120. Full size, off our own shelf and sealed. We choose which one, and you find out when you open the box.

Shipping and returns

Storage and handling

Supplied as lyophilized powder.

Storage Store at -20°C. Keep away from light.

Reconstitution solvents and the rest of the bench consumables are in Lab Essentials, and the FAQ covers handling questions.

Research use only. Sold strictly for in-vitro laboratory research by qualified professionals. Not for human or veterinary use.

Literature and regulatory sources relating to SLU-PP-332. The numbered markers in the description link to the entry they support, and every link opens on the publisher's own site.

B
[1]A Synthetic ERRα Agonist Induces an Acute Aerobic Exercise Response and Enhances Exercise Capacity
bioRxiv2022
biorxiv.org
C
[2]Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function
Circulation
ahajournals.org
P
[3]Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney
PubMed Central
pmc.ncbi.nlm.nih.gov
P
[4]Analysis and Identification of In Vitro Metabolites of Exercise Mimetic SLU-PP-332 ERRα/β/γ Agonist for Doping-Control Purposes
PubMed
pubmed.ncbi.nlm.nih.gov
P
[5]Chemical optimization of the exercise mimetic SLU-PP-332 enables insight into estrogen-related receptor signaling
PubMed
pubmed.ncbi.nlm.nih.gov

Questions about SLU-PP-332

What purity is SLU-PP-332?

SLU-PP-332 is synthesised to a ≥99% purity specification and supplied as lyophilized powder in a sealed glass vial. The specification is the standard the compound is made to, and it is listed with the rest of its specifications on this page.

How should SLU-PP-332 be stored?

Store at -20°C. Keep away from light. Lyophilized vials keep best at -20°C, protected from light and moisture; short-term storage at 4°C is acceptable, and the powder is stable at room temperature for the time it spends in the post.

What comes with SLU-PP-332?

Each unit is one sealed glass vial of lyophilized powder. Nothing to reconstitute it with is included: bacteriostatic water and the rest of the bench consumables are sold separately under Lab Essentials.

How fast is UK delivery?

Orders placed and paid before 2pm on a business day (Monday to Friday, excluding UK public holidays) are dispatched the same day via Royal Mail Tracked 24 in discreet, protective packaging, and arrive usually the next working day after dispatch. Standard shipping is £4.99, free on orders over £80, and orders over £120 arrive with a free research vial. We ship within the United Kingdom only.

Can I change my mind and return an order?

If you are buying as a consumer, yes: you have 14 days from delivery to cancel, without giving a reason, under the Consumer Contracts Regulations 2013. Tell us within 14 days, send the sealed vials back within 14 days, and we refund the goods plus the original delivery charge within 14 days. Return postage is at your cost unless the item was faulty or wrong. Opened vials are the one exception: our vials are sealed sterile, and regulation 28(3)(b) puts sealed goods that cannot be resold once unsealed, for health and hygiene reasons, outside the cancellation right.

Is SLU-PP-332 for human use?

No. SLU-PP-332 is supplied strictly for in-vitro laboratory research by qualified professionals. It is not a drug, food, cosmetic or supplement, it is not intended for human or veterinary use, and we do not provide dosage or administration guidance of any kind.

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SLU-PP-332 · UK research stock

About SLU-PP-332