Metabolic

SLU-PP-332 · UK research stock

Name: SLU-PP-332
Brand: Pepts
SKU: SLUPP332-5
Availability: OutOfStock

Synthetic pan-ERR agonist small molecule studied as an exercise mimetic in metabolic research

Size

£24.90

SKU SLUPP332-5 · Out of stock

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Same-day dispatch on orders before 2pm (Mon–Fri) · Royal Mail Tracked 24

Free shipping on orders over £80

Free research vial with every order over £120

Research use only. This product is sold strictly for in-vitro laboratory research by qualified professionals. It is not for human or veterinary use.

About SLU-PP-332

A synthetic small molecule, not a peptide, SLU-PP-332 belongs to a series of estrogen-related receptor (ERR) agonists developed from a pyrimidinetrione scaffold. It is an analogue built by medicinal chemistry rather than a fragment or copy of anything endogenous. The parent compound acts as a pan-ERR agonist with roughly four to fivefold selectivity for ERRalpha over ERRgamma ^[1]. ERRs are orphan nuclear receptors that govern transcriptional programmes for mitochondrial biogenesis and fuel selection.

Most of the interest comes from its description as an exercise mimetic. In mouse work, treatment induced DDIT4 through ERRalpha and switched on a transcriptional programme resembling the response to a bout of aerobic exercise ^[1]. Reported outcomes in those animals included more oxidative muscle fibres, higher fatty acid oxidation and greater running endurance ^[1]. Related pan-ERR agonists from the same programme have been studied in heart failure models, where the proposed mechanism is improved cardiac fatty acid metabolism and mitochondrial function ^[2]. ERR agonism has also been examined in the ageing kidney, again with mitochondrial function and inflammation as the readouts ^[3].

The evidence base is preclinical and small. It rests on cell assays and rodent models from a limited number of laboratories; there are no clinical trials, and the compound holds no medicines approval in the UK or elsewhere. Anti-doping chemists have characterised its in vitro metabolites for detection purposes, which indicates expected misuse in sport rather than any accepted use ^[4].

Because it is a small molecule, handling differs from the peptides it is often shelved beside. Rapid clearance in rodents prompted follow-up chemistry on the scaffold, yielding analogues such as SLU-PP-915 and other optimised ERR agonists ^[5].

Also sold as

SLU-PP-322

Research area

Metabolic

Purity

≥99% (HPLC)

Form

Lyophilized powder

Sizes

5 mg

Storage

Store at -20°C. Keep away from light.

Sizes, codes and availability
Size	SKU	Price	Availability
5 mg	SLUPP332-5	£24.90	Out of stock

Dispatch and delivery

Orders placed before 2pm Monday to Friday are dispatched the same day, by Royal Mail Tracked 24 in discreet packaging.

Shipping is £4.99, free on orders over £80.

A free research vial comes with every order over £120. Full size, off our own shelf, sealed and COA-backed. We choose which one, and you find out when you open the box.

Shipping and returns

Storage and handling

Supplied as lyophilized powder.

Storage Store at -20°C. Keep away from light.

Reconstitution solvents and the rest of the bench consumables are in Lab Essentials, and the FAQ covers handling questions.

Research use only. Sold strictly for in-vitro laboratory research by qualified professionals. Not for human or veterinary use.

Batch certificate

No certificate is published for the current batch of SLU-PP-332 yet. Every production batch goes to an independent laboratory before it ships, and its certificate appears in the COA hub under the batch number printed on the vial.

Already holding a vial? The verifier reads any batch number we have published.

Browse the COA hub Verify a batch

How every batch is tested

1Synthesised to specSynthesised to a ≥99% purity specification and filled as lyophilized powder into sealed glass vials.
2Independently testedEvery production batch goes to an independent analytical laboratory: HPLC quantifies purity, LC-MS confirms identity.
3Certificate publishedThe batch certificate is published in our COA hub and the batch number is printed on the vial. Batches under 99% are rejected.
4Verifiable by youType the batch number from your vial into the verifier and read the purity result, the lab and the test date.

Read the quality page

Literature and regulatory sources relating to SLU-PP-332. The numbered markers in the description link to the entry they support, and every link opens on the publisher's own site.