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Cognitive Research

Pinealon · UK research stock

Synthetic Glu-Asp-Arg tripeptide studied in neuroprotection and oxidative-stress models

Pinealon 10 mg research vial

Size

£34.99

SKU PINEALON-10 · In stock

Quantity

1

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Same-day dispatch on orders before 2pm (Mon–Fri) · Royal Mail Tracked 24

Free shipping on orders over £80

Free research vial with every order over £120

Research use only. This product is sold strictly for in-vitro laboratory research by qualified professionals. It is not for human or veterinary use.

About Pinealon

Pinealon is a synthetic tripeptide, Glu-Asp-Arg, also written EDR after the one-letter codes of its three amino acids. It comes from the Saint Petersburg Institute of Bioregulation and Gerontology, where Vladimir Khavinson's group studies very short peptides as regulators of gene activity [1]. Almost everything published on it comes from Russian laboratories, much of it from that group.

The research centres on neuroprotection under oxidative stress. In cultured cerebellar granule cells, neutrophils and PC12 cells, pinealon limited the build-up of reactive oxygen species and reduced necrotic cell death, alongside a delayed time course of ERK1/2 activation and changes in the cell cycle [1]. In a rat model of prenatal hyperhomocysteinaemia, treating pregnant dams was reported to improve their offspring's spatial learning and the resistance of their cerebellar neurons to oxidative stress [2]. In mouse hippocampal neurons exposed to amyloid, a cell model of Alzheimer's disease, the EDR peptide restored the number of mushroom-type dendritic spines [4].

The proposed mechanism is unusual for a peptide. Fluorescence-labelled pinealon has been seen inside the cell nucleus of HeLa cells, and in vitro it interacts with DNA in a sequence-dependent way [5]. The group's review proposes that it acts on the expression of genes such as caspase-3, SOD2 and the PPARs, and on MAPK/ERK signalling [3].

The evidence is early and narrow. It rests on cell work, rodent models and a few small human studies published in Russian, such as a 32-person study of biological-age markers in adults aged 41 to 83 [6]. There are no large controlled trials.

Specifications

Research area

Cognitive Research

Purity

≥99%

Form

Lyophilized powder

Sizes

10 mg

CAS number

175175-23-2

Molecular formula

C15H26N6O8

Molecular weight

418.4 g/mol

Storage

Store at -20°C. Keep away from light.

Additional information

Sizes, codes and availability
SizeSKUPriceAvailability
10 mgPINEALON-10£34.99In stock

Dispatch and delivery

Orders placed before 2pm Monday to Friday are dispatched the same day, by Royal Mail Tracked 24 in discreet packaging.

Shipping is £4.99, free on orders over £80.

A free research vial comes with every order over £120. Full size, off our own shelf and sealed. We choose which one, and you find out when you open the box.

Shipping and returns

Storage and handling

Supplied as lyophilized powder.

Storage Store at -20°C. Keep away from light.

Reconstitution solvents and the rest of the bench consumables are in Lab Essentials, and the FAQ covers handling questions.

Research use only. Sold strictly for in-vitro laboratory research by qualified professionals. Not for human or veterinary use.

Tags

tripeptideneuroprotectionbioregulator

Published research

Literature and regulatory sources relating to Pinealon. The numbered markers in the description link to the entry they support, and every link opens on the publisher's own site.

  1. R
    [1]Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes
    Rejuvenation Research2011Preclinical (in vitro)

    pubmed.ncbi.nlm.nih.gov

  2. I
    [2]Pinealon protects the rat offspring from prenatal hyperhomocysteinemia
    International Journal of Clinical and Experimental Medicine2012Preclinical (rat)

    pubmed.ncbi.nlm.nih.gov

  3. M
    [3]EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer's Disease
    Molecules2020Review

    pubmed.ncbi.nlm.nih.gov

  4. B
    [4]Tripeptides Restore the Number of Neuronal Spines under Conditions of In Vitro Modeled Alzheimer's Disease
    Bulletin of Experimental Biology and Medicine2017Preclinical (in vitro)

    pubmed.ncbi.nlm.nih.gov

  5. B
    [5]Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA
    Biochemistry (Moscow)2011Preclinical (in vitro)

    pubmed.ncbi.nlm.nih.gov

  6. A
    [6]Effect of synthetic peptides on aging of patients with chronic polymorbidity and organic brain syndrome of the central nervous system in remission
    Advances in Gerontology2015Clinical (small, in Russian)

    pubmed.ncbi.nlm.nih.gov

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